Muscular Dystrophy Canada in partnership with the Neuromuscular Disease Network for Canada's Clinical Trial Network to host the second Hope on the Horizon event. These events are geared towards patients and family members within the neuromuscular community. In this session, you'll learn about the treatment and clinical trial landscape for Myotonic Dystrophy from key experts in the field - Drs. Charles Kassardjian, Hanns Lochmüller and Cynthia Gagnon. - Are you or someone you know living with a neuromuscular disorder? We’re here to help. Muscular Dystrophy Canada has a wide range of programs and services designed to meet you where you are. Whether it is information about a disorder, helping you with accommodation needs at work or school, navigating the healthcare system, housing or financial issues, or helping you secure equipment – we’re here to help. Register today and our Service Specialists will be happy to work alongside you, ensuring you have the information and support you need. For more information: • Visit us online at: https://muscle.ca/access-help/ • Call us a: 1-800-567-2873 • Or, email info@muscle.ca You can also: • Check out our educational webinars: https://muscle.ca/discover-md/webinars/ • Register for one of our fundraising events: https://muscle.ca/events/ • Ask our Research team questions by emailing research@muscle.ca • Make a donation at muscle.ca/donate Follow us on: • Twitter: https://twitter.com/MD_Canada • Facebook: https://www.facebook.com/MuscularDystrophyCA • Instagram: https://www.instagram.com/md_canada/ • LinkedIn: https://www.linkedin.com/company/muscular-dystrophy-canada/

Each year, Muscular Dystrophy Canada invests in cutting-edge research that fuels future discoveries and advances treatments, therapies and potential cures. Thanks to generous giving, these grants will ensure that the Canadian neuromuscular community has access to life-changing treatment and care options today, tomorrow, and forever. 2025 CLINICAL AND TRANSLATIONAL SCIENCE RESEARCH GRANT RECIPIENTS: Dr Carolina Barnett-Tapia MD PhD Multimodal remote screening for bulbar dysfunction in myasthenia gravis – University Health Network Toronto General Hospital Dr Cynthia Gagnon PhD Selecting a patient-reported outcome to enhance dysphagia assessment in myotonic dystrophy type 1 and Friedreich ataxia – Université de Sherbrooke Dr Jodi Warman-Chardon MD PhD FRCPC (Neurology) Biomarker discovery in inclusion body myositis – Ottawa Hospital Research Institute Dr Melissa Fiscaletti MD FRCP(C) MSc Harnessing polygenic risk scores to transform osteoporosis screening in Duchenne muscular dystrophy – Centre hospitalier universitaire Sainte-Justine Dr Vincent Picher-Martel MD Development of antisense oligonucleotide therapy for oculopharyngeal muscular dystrophy using advanced 3D tissue modeling – Centre de recherche du CHU de Québec-Université Laval Dr Marie-Claude Sincennes PhD Analysis of tissue organization and cell type-specific defects in oculopharyngeal muscular dystrophy – National Institute of Scientific Research Dr Mark Currie PhD Developing a reporter system for rapid screening of drugs to treat Emery-Dreifus muscular dystrophy – University of Toronto Dr Yan Burelle PhD Targeting mitochondrial quality control to promote muscle regeneration in Duchenne muscular dystrophy – University of Ottawa Dr Toshifumi Yokota PhD FCAHS Development of an enhanced antisense therapy using lipid nanoparticles for Friedreich ataxia and spinobulbar muscular atrophy – University of Alberta To learn more about research advancements and the incredible projects that will improve our understanding and drive the development of new treatments and cures for NMDs, visit https://muscle.ca/services-support/research/research-grants/

Muscular Dystrophy Canada (MDC) is pleased to present a webinar on addressing sexuality in people with neuromuscular disorders (NMDs). By the end of the 1-hour webinar, we hope to have answered the following questions: •What is sexuality and why is it important to address in NMDs? •How do impairments in NMDs impact sexuality? •How can individuals with NMDs approach the topic of sexuality with their healthcare providers •How can rehabilitation specialists approach the subject of sexuality in people with NMDs? You can also explore the following resources on sexuality that were discussed during the webinar: Physiotherapy to Promote Sexuality in Adults with Neuromuscular Disease: https://savoirs.usherbrooke.ca/bitstream/handle/11143/19131/Clinical%20practice%20guideline%20physiotherapy%20and%20sexuality%20in%20neuromuscular%20disease_EN.pdf?sequence=4&isAllowed=y Occupational Therapy to Promote Sexuality in Adults with Neuromuscular Disease: https://savoirs.usherbrooke.ca/bitstream/handle/11143/22400/occupational_therapy_practice_guideline_GRIMN_2024.pdf?sequence=4&isAllowed=y Teens, Sex, and Neuromuscular Conditions: https://hollandbloorview.ca/sites/default/files/2023-11/Teens%2C%20Sex%20Neuromuscular%20GUIDE-Accessible.pdf Disability Sexuality Resource Hub: https://hollandbloorview.ca/disability-sexuality-resource-hub If you have any questions about the webinar or the resources shared, please feel free to reach out to us at research@muscle.ca - Are you or someone you know living with a neuromuscular disorder? We’re here to help. MDC has a wide range of programs and services designed to meet you where you are. Whether it is information about a disorder, helping you with accommodation needs at work or school, navigating the healthcare system, housing or financial issues, or helping you secure equipment – we’re here to help. Register today and our Service Specialists will be happy to work alongside you, ensuring you have the information and support you need. For more information: • Visit us online at: https://muscle.ca/access-help/ • Call us a: 1-800-567-2873 • Or, email info@muscle.ca You can also: • Check out our educational webinars: https://muscle.ca/discover-md/webinars/ • Register for one of our fundraising events: https://muscle.ca/events/ • Ask our Research team questions by emailing research@muscle.ca • Make a donation at muscle.ca/donate Follow us on: • Twitter: https://twitter.com/MD_Canada • Facebook: https://www.facebook.com/MuscularDystrophyCA • Instagram: https://www.instagram.com/md_canada/ • LinkedIn: https://www.linkedin.com/company/muscular-dystrophy-canada/

Muscular Dystrophy Canada is pleased to host a special webinar focused on cognitive and neurobehavioral symptoms in Myotonic Dystrophy. This webinar will spotlight updates from a project funded by Muscular Dystrophy Canada offering the latest research and findings. If you have any questions, please email research@muscle.ca - Are you or someone you know living with a neuromuscular disorder? We’re here to help. MDC has a wide range of programs and services designed to meet you where you are. Whether it is information about a disorder, helping you with accommodation needs at work or school, navigating the healthcare system, housing or financial issues, or helping you secure equipment – we’re here to help. Register today and our Service Specialists will be happy to work alongside you, ensuring you have the information and support you need. For more information: • Visit us online at: https://muscle.ca/access-help/ • Call us a: 1-800-567-2873 • Or, email info@muscle.ca You can also: • Check out our educational webinars: https://muscle.ca/discover-md/webinars/ • Register for one of our fundraising events: https://muscle.ca/events/ • Ask our Research team questions by emailing research@muscle.ca • Make a donation at muscle.ca/donate Follow us on: • Twitter: https://twitter.com/MD_Canada • Facebook: https://www.facebook.com/MuscularDystrophyCA • Instagram: https://www.instagram.com/md_canada/ • LinkedIn: https://www.linkedin.com/company/muscular-dystrophy-canada/

Muscular Dystrophy Canada (MDC) is pleased to present a webinar on myotonic dystrophy type 1 (DM1) in recognition of DM1 Awareness Day on September 15, 2023. While there is no cure for DM1, there is currently exciting research on treatment breakthroughs. Some of which will be discussed in the webinar. By the end of this webinar, we hope the following questions will be answered: 1. What is myotonic dystrophy? 2. What is the importance of skeletal muscle tissue formation (i.e.,myogenesis) in myotonic dystrophy type 1? 3. What are senescent cells and what is their connection to myotonic dystrophy type 1? 4. What is the future of research on myotonic dystrophy? 5. What is the current clinical trial landscape for myotonic dystrophy? 6. What therapies are in the treatment pipeline? Speakers: Dr. Nicolas Dumont, PT., PhD. Dr. Elise Duchesne, PT., PhD. If you have any questions, please email research@muscle.ca --------------- Are you or someone you know living with a neuromuscular disorder? We’re here to help. MDC has a wide range of programs and services designed to meet you where you are. Whether it is information about a disorder, helping you with accommodation needs at work or school, navigating the healthcare system, housing or financial issues, or helping you secure equipment – we’re here to help. Register today and our Service Specialists will be happy to work alongside you, ensuring you have the information and support you need. For more information: • Visit us online at: https://muscle.ca/access-help/ • Call us a: 1-800-567-2873 • Or, email info@muscle.ca You can also: • Check out our educational webinars: https://muscle.ca/discover-md/webinars/ • Register for one of our fundraising events: https://muscle.ca/events/ • Ask our Research team questions by emailing research@muscle.ca • Make a donation at muscle.ca/donate Follow us on: • Twitter: https://twitter.com/MD_Canada • Facebook: https://www.facebook.com/MuscularDystrophyCA • Instagram: https://www.instagram.com/md_canada/ • LinkedIn: www.linkedin.com/company/muscular-dystrophy-canada

This #LetsTalkNMD webinar is primarily targeted at Canadian clinicians, academics, and trainees with an interest in neuromuscular disorders. Speaker: Dr. Keiko Shikako-Thomas, PhD, OT/erg. Moderator: Dr. Cynthia Gagnon Learning Objectives: 1. Showcase KT products such as the Jooay app and the Knowledge Translation program at the CHILD-BRIGHT SPOR and how it could be applied to rare disease in the pediatric field, with a focus on leading KT innovation and how to engages different populations. 2. Reflect on KT practice in participatory research. 3. Understand practical applications of KT science. *********************************************************************** If you have any questions, please reach out to us at research@muscle.ca Donate today: http://muscle.ca/donate Follow us on: Facebook: https://www.facebook.com/MuscularDyst... Twitter: https://twitter.com/MD_Canada Instagram: https://www.instagram.com/md_canada/ LinkedIn: https://www.linkedin.com/company/musc... Website: http://www.muscle.ca

Si vous avez des questions, veuillez nous contacter à l'adresse research@muscle.ca. sous-titres: Sur votre bureau : • Cliquez sur l'icône en forme d'engrenage. • Si des sous-titres sont disponibles pour une vidéo, faites un choix dans la liste disponible. • Vous pouvez également cliquer sur l'icône CC. Une ligne rouge apparaîtra lorsque les sous-titres ont été activés. Sur votre téléphone cellulaire : • Appuyez sur le bouton menu (icône avec les trois points) dans le coin supérieur droit. • Appuyez sur l'icône CC, ou Sous-titres, dans le menu. • Sélectionnez le type de sous-titres que vous préférez. *********************************************************************** Faites un don aujourd'hui : http://muscle.ca/donner *********************************************************************** Suivez-nous sur : Facebook : https://www.facebook.com/DystrophieMusculaireCanada Twitter : https://twitter.com/Action_Musclee Instagram : https://www.instagram.com/md_canada/ LinkedIn : https://www.linkedin.com/company/muscular-dystrophy-canada/ Site Internet : http://www.muscle.ca/fr

An informative webinar given by Dr. Cynthia Gagnon to increase awareness of the DM experience. Hosted by Muscular Dystrophy Canada. If you have any questions, please reach out to us at research@muscle.ca For subtitles: On Desktop: • Click the gear icon. • If subtitles are available for a video, make a choice from the available list. • Alternatively, click the CC icon. A red line will appear when closed captions have been enabled. On Mobile: • Tap the three-dot menu in the upper right corner. • Tap the CC icon, or Captions, in the menu. • Select the type of captioning you prefer. *********************************************************************** Donate today: http://muscle.ca/donate *********************************************************************** Follow us on: Facebook: https://www.facebook.com/muscle.ca/ Twitter: https://twitter.com/MD_Canada Instagram: https://www.instagram.com/md_canada/ LinkedIn: https://www.linkedin.com/company/muscular-dystrophy-canada Website: http://www.muscle.ca

If you have any questions, please reach out to us at research@muscle.ca For subtitles: On Desktop: • Click the gear icon. • If subtitles are available for a video, make a choice from the available list. • Alternatively, click the CC icon. A red line will appear when closed captions have been enabled. On Mobile: • Tap the three-dot menu in the upper right corner. • Tap the CC icon, or Captions, in the menu. • Select the type of captioning you prefer. *********************************************************************** Donate today: http://muscle.ca/donate *********************************************************************** Follow us on: Facebook: https://www.facebook.com/muscle.ca/ Twitter: https://twitter.com/MD_Canada Instagram: https://www.instagram.com/md_canada/ LinkedIn: https://www.linkedin.com/company/muscular-dystrophy-canada Website: http://www.muscle.ca